Cloverleaf Bio is developing engineered transfer RNA therapies that use a modified tRNA payload to inhibit cancer cells' RNA-modifying enzymes. Its lead program targets liver cancer and is advancing toward clinical testing; a second antibody-tRNA program for colorectal cancer remains preclinical.
AV
AbbVie Ventures
Activity from announced rounds
Activity in this selectionOct 18, 2026 · Jul 21, 2026
AbbVie Ventures is AbbVie’s corporate venture investment arm. Company and university announcements identify it as an investor in Third Arc Bio and Cloverleaf Bio.
Recorded funding activity
The two companies pursue different therapeutic approaches. Third Arc develops multifunctional antibodies for oncology and immunology; Cloverleaf engineers transfer RNA for cancer treatment. The recorded activity includes Third Arc’s Series A extension and Cloverleaf’s seed financing, linking AbbVie Ventures to both later syndicate support and early company formation.
- Rounds participated in
- 1
- Confirmed lead rounds
- 0 All roles disclosed
- New companies
- 1 First participation on record · 0 follow-on
- Funding in participating rounds
- $33M 1 disclosed · full round size, not this investor’s share
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Rounds
1 in this selectionCloverleaf Bio
$33MSeed
Participant